Reduction in Intracellular Calcium Levels Inhibits Myoblast Differentiation
نویسندگان
چکیده
منابع مشابه
Stac3 Inhibits Myoblast Differentiation into Myotubes
The functionally undefined Stac3 gene, predicted to encode a SH3 domain- and C1 domain-containing protein, was recently found to be specifically expressed in skeletal muscle and essential to normal skeletal muscle development and contraction. In this study we determined the potential role of Stac3 in myoblast proliferation and differentiation, two important steps of muscle development. Neither ...
متن کاملCorrection: Stac3 Inhibits Myoblast Differentiation into Myotubes
Citation: The PLOS ONE Staff (2014) Correction: Stac3 Inhibits Myoblast Differentiation into Myotubes. PLoS ONE 9(8): e105240. doi:10.1371/journal. pone.0105240 Published August 7, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any m...
متن کاملThe block of ryanodine receptors selectively inhibits fetal myoblast differentiation.
Differentiation and morphogenesis of skeletal muscle are complex and asynchronous events that involve various myogenic cell populations and extracellular signals. Embryonic and fetal skeletal myoblasts are responsible for the formation of primary and secondary fibers, respectively, although the mechanism that diversifies their fate is not fully understood. Calcium transients appear to be a sign...
متن کاملHDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription
Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that regulate muscle differentiation will be useful in the treatment and prevention of these conditions. Protein lysine acetylation and methylation are major post-translational modification mechanisms that regulate key cellular pro...
متن کاملGrowth and differentiation factor-11 is developmentally regulated in skeletal muscle and inhibits myoblast differentiation
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal muscle growth remains unclear and the pattern of expression during post-natal growth has not been reported. Therefore, we sought to determine the expression of GDF-11 during post-natal growth and its...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m203961200